Philadelphia’s Saquon Barkley’s record-breaking season in 2024-25 earned him NFL Offensive Player of the Year honors.
But that was last season.
Could the Philly star be upended at the conclusion of this NFL campaign?
Let’s check out the odds at DraftKings Sportsbook as of Oct. 21, as well as what to know about each leading candidate.
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2025-26 Offensive Player of the Year
Jonathan Taylor, RB, Colts: +100
What to know: Colts’ workhorse running back Jonathan Taylor has helped the team reach their surprising 6-1 record. His 697 yards on the ground are a league-best, as are his 10 touchdowns. After the Colts defeated the Cardinals in Week 6, his odds shortened to +175 from +300, moving him into the top spot. And after his 94-yard, three-touchdown performance in Week 7, his odds moved even more to +100.
Jaxon Smith-Njigba, WR, Seahawks: +400
What to know: Smith-Njigba has an incredible 819 receiving yards on the season (first), four TDs and 50 receptions (tied for fifth). In Seattle’s Week 7 win over Houston, he had 123 receiving yards, and his odds in this market moved to +400 from +475.
Christian McCaffrey, RB, 49ers: +550
What to know: It’s business as usual for dual-threat back McCaffrey. He has 132 carries (first), 465 rushing yards and 516 receiving yards through seven weeks for the 5-2 49ers.
Bijan Robinson, RB, Falcons: +950
What to know: Through seven weeks, Robinson has 524 rushing yards and 390 receiving yards — a true-dual threat back. After his 170-yard rushing, 68-yard receiving Week 6 performance in the Falcons’ win at home over Buffalo, his odds moved to +400. His numbers in Week 7 dropped off, as the RB had 40 rushing yards and 52 receiving.
Puka Nacua, WR, Rams: +1100
What to know: In Week 6, Puka suffered an ankle injury in the Rams’ 17-3 win over the Ravens. Lucky for L.A. — and for Nacua — he avoided a season-ending injury and instead, is listed as day-to-day. He has the second-most receptions (54) and the third-most receiving yards (616) in the NFL.
Ja’Marr Chase, WR, Bengals: +1200
What to know: Chase’s 58 receptions are best in the NFL and his 629 yards are good for second. In Cincy’s 33-31 Week 7 win over Pittsburgh, he had 161 yards and a touchdown.
Jahmyr Gibbs, RB, Lions: +2200
What to know: Gibbs is helping give Detroit’s offense a boost. He’s got six TDs and 526 rushing yards so far this season.
Amon-Ra St. Brown, WR, Lions: +2800
What to know: Brown’s 50 receptions are tied for fifth in the NFL and his seven TDs are best in the league. He also has 538 receiving yards on the season (fifth).
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